![]() Upon execution of the file “fedex,pdf.exe”, the executable creates a new process of the Windows CLI tool “RegAsm” and injects a malicious payload into it leading to networking communication with the C2 Boki0419duckdnsorg on port 9900.įigure 6: The network activity of RegAsm process via Process Hacker tool Analyzing the executable file with DiE (Detect it Easy) suggests that the file was likely packed due to the unusual imports, and lack of strings.įigure 5: Detect It Easy tool assessment on the executable “fedex,pdf.exe” Upon opening the ISO, we were presented with an executable file “fedex,pdf.exe”. Disk image tool pdf#This ISO contains a single binary executable in it called “fedex,pdf.exe”, this binary was disguised with a PDF logo as shown in Figure 4.įigure 4: Executable inside the ISO using a fake PDF logo and PDF extension Disk image tool archive#The ISO archive had a relatively low detection on VirusTotal (18/70). Disk image tool update#The lure was short and precise suggesting failure to deliver a FedEx parcel due to incorrect address, while guiding the victim to download the attached document from FedEx to update their address.įigure 3: Google Translate used to translate the message to EnglishĬlicking on the link (hxxp://madridbgcom/FedEx,pdf.iso) downloaded an ISO archive called “FedEx,pdf.iso”. The email was drafted in the French language, hence targeting French speakers. ISO disc image files when they are opened, hence making them a hot commodity for scammers.įigure 2: Screenshot of the email message as displayed to a victim Recent versions of Microsoft Windows 10 and Windows 8 have the built-in ability to mount. Malware authors have started abusing these archives by re-purposing them to deliver malware. They are often used for backing up optical discs, or for distributing large file sets. The message tricked the victims to click on a link that downloaded an ISO archive containing a single executable of the Nanocore RAT.Īn ISO file (often called an ISO image), is a well-known archive file of optical discs like CD/DVD. The first campaign was a fake FedEx shipment email message targeting some of our European customers. In this blog, we will present two recent malspam campaigns that utilize disk image formats in delivering malware through phishing links and as attachments.įigure 1: Attack flow illustrated here shows disk imaging software like ISO or DAA files are sent as an email attachment or hosted at a site pointed to via a link in an email to infect victims with RATs. Disk imaging software includes formats like ISO, IMG, VHD, VDI, VMDK, VHD and DAA etc. It saves the entire data from the disk, including the file structure and all files and folders, in a single file and thus often serves as a full backup. ISO archives attributing to 6% of all malware attachment archives seen this year.Ī disk image is a software copy of a physical disk. ISO) being used as a container for serving malware via email, with. This year we observed a notable uptick in disc imaging software (like. Authors: Diana Lopera, Joshua Deacon, and Fahim Abbasi ![]()
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![]() Security and durability were our next concerns. For this reason, we did an in-depth dive looking into the various styles (slim or clunky), whether the case comes in more colors than your standard grey or black, and how many ports it has to accommodate your charger, headphones, and any memory sticks you may need to use. From a design standpoint, we know you’re looking for something stylish that isn’t an eyesore and can also accommodate all of your USBs or chargers. This is why we took extra care to look at the size of each case, whether it is lightweight or not, and whether it is easily portable. #Layers of fear 2 safe combo portableYour keyboard case ought to be able to fit into your lifestyle (and bags!), be light enough to carry around, as well as be portable enough so that you don’t have to plan your entire trip around it. #Layers of fear 2 safe combo proWith all of these first-hand opinions coming from a wide range of Pro keyboard case users, you can be assured that we’ll help you find the perfect item for you. We took into account whether previous customers were using their Pro keyboard cases for studying, professional use, to assist in their hobbies, or if they were simply looking for something to keep their leisure use device safe. To make the process easier, we paid great attention to what previous customers had to say about the products we reviewed. The Magic Keyboard is heavier, though, and pricer, so these are the things to bear in mind when choosing between the two.įinding the right Pro keyboard case for you wasn’t easy, especially considering the wide range of usage for the variety of lifestyle needs you all have. The magic keyboard is attached magnetically to your device, which makes it easier to charge both devices and travel easily. The smart keyboard lacks backlighting, so you won’t be able to use it in a dark room or bed without disturbing your partner. In terms of efficiency, a magic keyboard is a better option. Besides, these cases add a layer of protection to the tablet.Ī Magic Keyboard provides a trackpad, which is a major advantage over the smart keyboard, for which you will still need to attach an external mouse to achieve the same function. That’s why a keyboard case is an absolute necessity. This makes it easier to hold and use with one hand, but it can make typing on the device difficult. The tablet is also significantly thinner than its predecessor. If you’re an avid iPad user, there’s a good chance you’re familiar with its larger size - and not just in terms of height. The products here advertised are for all individuals who are looking to take their iPad keyboard case use experience to new heights! ![]() ![]()
Click the tab labelled Rebuild DB, then allow some time for the sounds to appear.In the software, navigate to: File > Options > Browser.If you do not find your user presets in the Name column of the Sounds Browser, you can re-scan the user folder location. The sound presets are then listed in the Name column. Any user sounds which have already been saved with a bank name attribute can be filtered out via the Bankname column. Check the Sounds Browser for your user-created presets.Windows: C: > Program Files > Native Instruments > Absynth 5.OS X: Macintosh HD > Applications > Native Instruments > Absynth 5.Open the standalone Version of ABSYNTH (for example) from this location of your computer:.This must be done first (before using the plug-in version) in order for the application to find and catalogue all Factory and User-Created sounds. Once you have transferred the user-preset-files to the same location on the new computer, be sure to launch the ABSYNTH, FM8, or MASSIVE (original) standalone application. Accessing User Presets on the New Computer #ABSYNTH PRESETS PORTABLE#Using a USB Flash Drive, External Hard Drive (or other portable storage media), transfer the Sounds folder into the same exact directory-location at the new computer.ģ.Windows: C: > Users > *User Name* > Documents > Native Instruments > *Product name* > Sounds.OS X: Macintosh HD > Users > *User Name* > Documents > Native Instruments > *Product name* > Sounds.Copy the Sounds folder which contains all the sound preset files you have created.īy default, the Sounds folder is located here:.In order to transfer the user-content (i.e. Transferring User-Presets from the Old Computer Only your unique user-sound-files are needed. There is no need to move the actual product software from the old computer. #ABSYNTH PRESETS INSTALL#Transferring the Applicationįirstly, install and activate the product on your new computer via Native Access. This article applies equally to all 3 instruments in the same context. Note: ABSYNTH, FM8, and MASSIVE (original) each employ the same type of preset browsing and file systems. #ABSYNTH PRESETS HOW TO#**You will need to move the samples included in this pack to the default Absynth location for the presets to load - please see the accompanying user guide for more information.This article shows how to transfer user-created sound presets for ABSYNTH, FM8, and MASSIVE from an older or existing computer, so that they will appear in the software browser on the new computer. *Please be aware that this is a preset pack for Native Instruments' Absynth soft synthesizer - you must own the latest version 5 to use these presets. you must own the latest version (Absynth 5) of Native Instrument's Absynth soft synth to use the presets in this pack.Īll content included in this preset pack is available 100% royalty free, so what are you waiting for? Get tweaking! "Which Massive Synth formats are included?" 64 presets for Native Instruments' Absynth soft synth, as well as the 37 associated audio samples. This pack has been made exclusively for use with Native Instruments' limitless Absynth, used by superstar sound designers across the world to create the freshest sounds in electronic music today. Trust us, we leave no rock unturned and have spent hours making sure every single sound is bang up-to-date with current musical flavors, tweaking every dial and slider to bring you the very best your synth has to offer. #ABSYNTH PRESETS FULL#These sounds are available in the form of presets, each one of which has been precision-designed by the Prime Presets team to make full use of all the oscillators, filters and routing options available in your synth. Inside this pack you'll find all the ambient inspiration you'll need, including delicate sub basses, gliding pads, ethereal synths, fractured SFX and more. Absynth like you never heard before Unleash this blue sound design monster, with extraordinary expansion packs, based on meticulously handcrafted high resolution samples. Welcome to Prime Presets, the brand new series of patches for all your favorite software synthesizers fresh from the Prime Loops audio scientists! ![]() ![]() This is a dramatic, almost flamboyant style that is not classic Pauillac in one sense, but a classic wine. The 2005 Pichon Longueville Comtesse de Lalande is made from 64 Cabernet Sauvignon, 29 Merlot, and 7 Cabernet Franc and Petit Verdot. The 2005 Pichon Lalande is not an inspiring wine, particularly within the context of the year and also the vintages that follow in this tasting. I suspect this wine will be relatively approachable young but evolve effortlessly. The wine is full-bodied, with extraordinary purity and a tremendous texture. As the 2000 sits in the glass, notes of lavender and melted licorice emerge along with the distinctive tapenade aromas interwoven with creme de cassis, espresso roast, and cedar. In the mouth, it is a wine of extraordinary density, opulence, great presence, and richness. The wines epitomise the remarkable balance of Pauillac, with a silky tannic structure along with an expressive and suave aromatic complexity. The 2005 Pichon Lalande, with its aromatics of cassis, forest floor and earth are followed by a medium-bodied wine that doesn have quite the length and. No doubt the Petit Verdot has imparted a certain almost olive-like component to the wine's aromatic profile. Relying on the best of traditional and modern methods, Château Pichon Longueville Comtesse de Lalande built new winemaking facilities in 2013. A blend of 50% Cabernet Sauvignon, 34% Merlot, 10% Petit Verdot, and the rest Cabernet Franc, this effort has a dense saturated purple color, a singular/distinctive yet possibly controversial aromatic smorgasbord existing of creme de cassis, vanilla, and violets, but also tapenade and tree bark. The 2000 Pichon-Longueville Comtesse de Lalande is spectacular, and certainly a noteworthy rival to the 1996, 1995, and even the extraordinary 1982. ![]() ![]() The lost watch 3d screensaver name and key movie#Rounding out the rest of the cast is Dianne Wiest as the sweet mother, Corey Haim and Edward Hermann as the vampire killing duo Edgar and Alan (a cute Poe reference) Frog and 80's movie staple Jamie Gertz as the gypsy-esque Star.(sidenote: Yes that is Alex Winter of "Bill and Ted" fame as one of the lesser vampires) The film has many memorable scenes including the vampire initiation and the scene where Patrick first approaches his brother in vampire form. Jason Patrick is as good as an actor could possibly be in a role that requires very little character development but the big star here is Kiefer Sutherland who channels his "scary bad boy" look into a character who is as fun to watch as he is frightening. Yeah, Corey Haim may not be a Dean or Brando, but he is pitch perfect as the annoying little brother who talks big and runs fast in the face of trouble. The makeup is top notch, as are the special effects and the acting is a perfect fit to the context of the film. The best element of this movie is that fact that it doesn't take itself very seriously, but in no way does that effect the relative creepiness of the main storyline. I loved this film as a kid and it has always stayed at the top of my vampire genre list, you could bet I was plenty surprised when I found out that this little jewel of 80's cinema was directed by the now yawn worthy "Phone Booth" helmer, Joel Scumacher (the man who massacred the "Batman" franchise). ![]() ![]() Sports, Fitness and Outdoors 15 Days Returnable Pet Habitats and Supplies, Apparel and Leashes, Training and Behavior Aids, Toys, Aquarium Supplies such as Pumps, Filters and Lights 15 Days Returnable Please see our Amazon International Store Returns policy for information about returning Amazon International Store items.ĭesktops, Monitors, Pen drives, Hard drives, Memory cards, Computer accessories, Graphic cards, CPU, Power supplies, Motherboards, Cooling devices, TV cards & Computing Components 15 Days Returnableĭigital Cameras, camera lenses, Headsets, Speakers, Projectors, Home Entertainment (new and certified refurbished) 15 Days Returnable To determine whether items sold and fulfilled by a third-party seller can be returned, check the returns policy set by the seller. Third-party sellers on Amazon.sg are expected to offer returns on an equivalent basis, but their policies may vary. Unless otherwise stated, original shipping charges will not be refunded on returns due to customer choice/error. #Usb c thunderbolt dockstation for 3 monitors fullReplacements are only available for items that are sold and fulfilled by Amazon SG – see About Replacements and Amazon.sg Refunds Policy.ĭamaged/defective or any Amazon error returns will receive a full refund including a refund of original shipping charges. When you return an item, you may see an option for a refund or replacement. Products are returnable on Amazon.sg within the 15 day return window for any reason on Amazon.sg. Video Games (Accessories and Games) 15 Days Returnable ![]() ![]() When the Senate would not command Pompey to give up his command simultaneously, Caesar, against regulations, led his forces across the Rubicon River (49) between Gaul and Italy, precipitating the Roman Civil War. After conducting the Gallic Wars, during which he invaded Britain (55, 54) and crossed the Rhine (55, 53), he was instructed by the Senate to lay down his command, Senate conservatives having grown wary of his increasing power, as had a suspicious Pompey. He formed the First Triumvirate with Pompey and Marcus Licinius Crassus in 60 and was elected consul in 59 and proconsul in Gaul and Illyria in 58. A patrician by birth, he held the prominent posts of quaestor and praetor before becoming governor of Farther Spain in 61–60. Julius Caesar, (born July 12/13, 100 bce, Rome-died March 15, 44 bce, Rome), Celebrated Roman general, statesman, and dictator. SpaceNext50 Britannica presents SpaceNext50, From the race to the Moon to space stewardship, we explore a wide range of subjects that feed our curiosity about space!.Learn about the major environmental problems facing our planet and what can be done about them! Saving Earth Britannica Presents Earth’s To-Do List for the 21st Century.Britannica Beyond We’ve created a new place where questions are at the center of learning.100 Women Britannica celebrates the centennial of the Nineteenth Amendment, highlighting suffragists and history-making politicians. When was julius caesar born how to#COVID-19 Portal While this global health crisis continues to evolve, it can be useful to look to past pandemics to better understand how to respond today.Student Portal Britannica is the ultimate student resource for key school subjects like history, government, literature, and more.This Time in History In these videos, find out what happened this month (or any month!) in history.#WTFact Videos In #WTFact Britannica shares some of the most bizarre facts we can find.Demystified Videos In Demystified, Britannica has all the answers to your burning questions.Britannica Explains In these videos, Britannica explains a variety of topics and answers frequently asked questions.Britannica Classics Check out these retro videos from Encyclopedia Britannica’s archives. ![]() ![]() This means to be stable the protein must place nonpolar, water-fearing residues on its surface, and pack its polar, water-loving residues inside. In membranes, however, protein folding is more complicated because the lipid interior of the membrane is non-polar, that is, it has no separation of electrical charges. Such residues are called hydrophobic or "water-fearing." As a result, the interaction between the water-loving and water-fearing residues of the protein and the surrounding watery fluids helps drive protein folding and stabilizes the protein's final structure. Non-polar residues, on the other hand, tend to be found packed within the protein core away from the polar aqueous fluid. As a result, polar residues on proteins are called hydrophilic, or "water-loving." In aqueous fluids, amino acid residues that have polar sidechains - components that can have a charge under certain physiological conditions or that participate in hydrogen bonding - tend to be located on the surface of the protein where they can interact with water, which has negatively and positively side charges to its molecule. The resulting models have been shown to accurately represent the structure the sequence will likely assume in nature.ĭetermining the structure of transmembrane proteins is difficult because portions of transmembrane proteins must pass though the membrane's interior, which is made of oily fats called lipids. It is not unusual for the program to create tens of thousands of model structures for an amino acid sequence and then identify the ones with lowest energy state. The Rosetta program used by Lu and his colleagues can predict the structure of a protein by taking into account these interactions and calculating the lowest overall energy state. Ultimately, the protein assumes the shape that best balances out all these factors so that the protein achieves the lowest possible energy state. The architecture of a protein is crucial because a protein's structure determines its function.Ī protein's shape forms from complex interactions between the amino acids that make up the protein chain and between the amino acids and the surrounding environment. In the new study, Lu and his coworkers used a computer program, developed in the Baker lab and called Rosetta, that can predict the structure a protein will fold into after it has been synthesized. Because they act while embedded within the cellular membrane, transmembrane proteins have proven to be more difficult to study than proteins that operate in the watery solution that make up the cells' cytoplasm or in the extracellular fluid. Peilong Lu, a senior fellow in the Baker lab, is the paper's lead author.īut understanding how transmembrane proteins are put together and how they work has proved challenging. The research is reported in the March 1 issue of the journal Science. "Our results pave the way for the design of multispan membrane proteins that could mimic proteins found in nature or have entirely novel structure, function and uses," said David Baker, a University of Washington School of Medicine professor biochemistry and director of the UW Institute of Protein Design who led the project. Because of such roles, many drugs are designed to target transmembrane proteins and alter their function. Some transmembrane proteins receive or transmit cell signals. For example, many naturally occurring transmembrane proteins act as gateways for the movement of specific substances across a biological membrane. They are essential for them to function normally. Our results pave the way for the design of multispan membrane proteins with new functions.In the living world, transmembrane proteins are found embedded in the membrane of all cells and cellular organelles. Crystal structures of the designed dimer and tetramer-a rocket-shaped structure with a wide cytoplasmic base that funnels into eight transmembrane helices-are very close to the design models. The designed proteins localize to the plasma membrane in bacteria and in mammalian cells, and magnetic tweezer unfolding experiments in the membrane indicate that they are very stable. We report the design of transmembrane monomers, homodimers, trimers, and tetramers with 76 to 215 residue subunits containing two to four membrane-spanning regions and up to 860 total residues that adopt the target oligomerization state in detergent solution. The computational design of transmembrane proteins with more than one membrane-spanning region remains a major challenge. It is now possible to create complex, custom-designed transmembrane proteins from scratch ! Today Baker lab members published in Science “ Accurate computational design of multipass transmembrane proteins” Designed Membrane Protein: (Left) Side view showing the designed membrane protein inside the membrane. ![]() ![]() Prioritize requests for system enhancements and coordinate follow-up with the RealPage or customer's product management group.Identify opportunities for ongoing learning to ensure Revenue Management is fully adopted by the customer.Maintain a working knowledge of the integration with each Property Management System.Effectively communicate technical items to IT Tech or Support and follow-up to ensure customer satisfaction.Efficiently run multiple projects and use Salesforce to track and update project steps.Articulate the revenue management value proposition and develop credibility for its concepts and benefits across client organizations.Consult with customers on parameter reviews and tuning.Consult with customers on operational questions related to Revenue Management.Regular discussions with site, regional and asset managers related to pricing questions.Review pricing recommendations with or on the customers behalf to ensure customer adoption and satisfaction.Build and maintain relationships with customers and internal RealPage staff.Revenue Managers collaborate with representatives at all levels of the organization to understand and implement strategy as well as track and review overall performance. The Revenue Management Advisor provides insight and advice to customers from both a Revenue Management and general operations perspective. Serving our clients is our highest priority and RealPage teammates are our greatest asset.Ĭome join a team where your work makes an impact every day! We navigate clients toward the right decisions with data and technology insights they can only get from RealPage. We are the leading global provider of software and data analytics to the real estate industry. If you want to join a globally progressive and inclusive company devoted to excellence, we are looking for you! YIELDSTAR ANYLIST HOW TORealPage is changing the technology real estate industry and our teammates know how to think big and leave their mark. ![]() ![]() We checked the resolution of our submitted figures, and we determine this issue should be specific to the reviewer copy only. The resolution of the figures in the main submission, but not the supplement, is a little poor in the review copy." I agree to the open peer review policy of the journal. I understand that any comments which I do not wish to be included in my named report can be included as confidential comments to the editors, which will not be published. Re binning scaffold meaning license#I agree for my report to be made available under an Open Access Creative Commons CC-BY license ( ). I understand that my name will be included on my report to the authors and, if the manuscript is accepted for publication, my named report including any attachments I upload will be posted on the website along with the authors' responses. I declare that I have no competing interests. If your reply is yes to any, please give details below. If you can answer no to all of the above, write 'I declare that I have no competing interests' below. Have you received reimbursements, fees, funding, or salary from an organization that holds or has applied for patents relating to the content of the manuscript?ĭo you have any other financial competing interests?ĭo you have any non-financial competing interests in relation to this paper? Have you in the past five years received reimbursements, fees, funding, or salary from an organisation that may in any way gain or lose financially from the publication of this manuscript, either now or in the future?ĭo you hold any stocks or shares in an organisation that may in any way gain or lose financially from the publication of this manuscript, either now or in the future?ĭo you hold or are you currently applying for any patents relating to the content of the manuscript? Please complete a declaration of competing interests, considering the following questions: You'd better clarify it somewhere in your manuscript. For example, you did not apply the 10X data to further scaffold the assembly, or maybe you have but I missed it. The authors may want to give the unbinned data based assembly a more integrity process, so that makes a fair comparison. Validating and visualizing those heterozygous sites makes the quality assessment part more complete. SNPs, small InDels and large structure variances(SVs). As you have already obtained the high-quality genome assembly, you may want to re-calculate it, and also it will be great to show readers that how the heterozygous sites distribute on the genome and briefly categorize them according to their types, e.g. The authors claim a whole genome heterozygosity level of 1.9% for the wood tiger moth, which, however, is estimated using a Kmer based method before obtaining the genome assembly. Will enlarge the K value help to increase the proportion and in turn, increase the power of the analysis? In addition, what is the proportion of your Kmer set that was utilized in the KAT analysis comparing to the entire Kmer set which can be obtained from the genome assembly or the shotgun reads. For example, how did you obtain the initial Kmer set, from your assemblies or the shotgun reads? If you distinguished single-copy and multiple copy Kmers by tallying their occurrence number in the parental and maternal genomes, how did you define those 0-copy Kmer? The authors may want to explain more on the results from the KAT (Kmer based) analysis. I recommend it be accepted for publication after addressing several minor issues as follows: Importantly, it will contribute the studies on entomological genomics and meets the scope of GigaScience. The manuscript was well written and all the materials and methods were presented in a clear and organized manner. The manuscript presents a haplotype-resolved genome assembly for the wood tiger moth that possesses a high-level whole genome heterozygosity level. ![]() |
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